Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway
نویسندگان
چکیده
منابع مشابه
Bovine parainfluenza type 3 virus infection: virus replication in bovine embryonic cell cultures and virion separation by rate-zonal centrifugation.
Replicative sequences of a bovine strain of parainfluenza type 3 virus in bovine embryonic kidney and spleen cell cultures were investigated by light and fluorescence microscopy and by ultrathin section and negative-contrast electron microscopy. Observations from light and fluorescence microscopy showed that intracytoplasmic inclusions were detected as small granules surrounding the nuclei of m...
متن کاملBovine parainfluenza type 3 virus infection: ultrastructural aspects of viral pathogenesis in the bovine respiratory tract.
After aerosolization of a bovine strain of parainfluenza type 3 virus, the pathogenesis of the virus was followed from the trachea to the bronchioalveolar compartments of the lung of colostrum-free calves and of conventionally reared calves during a 5- to 12-day postexposure interval. By tissue titration, plaque assay, and electron microscopy, it was found that virus infection could be establi...
متن کاملDeterminants of the host range restriction of replication of bovine parainfluenza virus type 3 in rhesus monkeys are polygenic.
The Kansas strain of bovine parainfluenza virus type 3 (BPIV3) is 100- to 1,000-fold restricted in replication in the respiratory tracts of nonhuman primates compared to human PIV3 (HPIV3), an important pathogen of infants and young children. BPIV3 is also restricted in replication in human infants and children, yet it is immunogenic and is currently being evaluated in clinical trials as a vacc...
متن کاملEffects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity.
A live attenuated bovine parainfluenza virus type 3 (PIV3), harboring the fusion (F) and hemagglutinin-neuraminidase (HN) genes of human PIV3, was used as a virus vector to express surface glycoproteins derived from two human pathogens, human metapneumovirus (hMPV) and respiratory syncytial virus (RSV). RSV and hMPV are both paramyxoviruses that cause respiratory disease in young children, the ...
متن کاملIsolation of Bovine Parainfluenza-3 Virus in Chick Embryos.
Myxovirus parainfluenza-3 (SF-4 bovine strain) was first isolated in tissue cultures of embryonic bovine kidney (EBK) cells (Reisinger, Heddleston, and Manthei, J. Am. Vet. Med. Assoc. 135:147, 1959). This agent is antigenically and biologically related to the human HA-1 strain isolated previously by Chanock et al. in monkey kidney cells (Abinanti and Huebner, Virology 8:391, 1959; Abinanti et ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2020
ISSN: 1746-6148
DOI: 10.1186/s12917-020-02291-w